Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 124
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124 NOTES ON THE NEWER REMEDIES.
substitute for the sodium salt, to which it is said to be
superior in chronic rheumatic affections.
Administration.-The daily dose of lithium salicylate
is I drachm (4 grammes).'
LOBELINE.
This alkaloid, extracted from the seeds and leaves of
Lobelia inf;ata, has not been studied in a thorough man-
ner chemically.
Physical Properties.-This alkaloidal principle ap-
pears as a yellowish liquid of the consistency of syrup.
The sulphate, however, is a yellowish-white powder.
Physiological Action.--Nrvous Systtnw.-Lobeine at
first produces an increase of reflex action, followed by a
diminution and final loss of the same. The drug acts
particularly on the motor nerves, paralyzing them.
Circulation.-This drug generally causes a rise of the
arterial pressure through a peripheral stimulation of the
vaso-motor system, and probably also by a direct car-
diac action. The pulse becomes irregular under the in-
fluence of the remedy, but there appears to be an increase
of power in the cardiac beat.
Respiration.-Lobline in small amounts acts as a res-
piratory stimulant, increasing the depth as well as the
rate of the movements. Large doses, however, produce
asphyxia and death, mainly through respiratory failure.
The action is chiefly on the respiratory centres, although
this drug is alleged to produce peripheral paralysis of
the pneumogastric fibres.
Therapeutic Applications.-This salt has been highly
recommended as an antispasmodic in the treatment of
asthma and bronchitis, especially in the spasmodic forms
of those disorders.
1 Lithium dithio-salicylale has been brought to the notice of the pro-
fession as a good remedy in the treatment of rheumatic disorders,
especially gout and arthritis.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/123/: accessed April 23, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.