Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 125

                                
L ORE TIN.

Administration.-The dose of the sulphate of lobeline
is from I to 6 grains (o.o6 to 0.36 gramme), given either
by the mouth or hypodermatically.
Toxicology.-The most prominent symptoms of poi-
soning produced by lobeline are-violent vomiting, and
sometimes purging; irrQl.ular respirationl followed by
phenomena of asphyxia; great prostration; cold sweat-
ing; livid face; pale skin; feeble pulse; sometimes burn-
ing in the fauces and oesophagus; dilated fixed pupil;
fall of the bodily temperature; muscular tremors,.con-
vulsions, stupor, and coma. Death is generally pro-
duced by failure of the respiration. In cases of poison-
ing the treatment should consist in washing out the
stomach with solutions of tannic acid; the administra-
tion of opium to allay pain, and that of alcohol, am-
monia, strychnine, and digitalis hypodermatically to sus-
tain the respiration and the action of the heart, together
with the active application of external heat.
LORETIN.
The above short name is given to meta-iodo-ortho-
ox)yqulo/i-anasullhonic acid, a new antiseptic remedy.
Physical Properties.-Loretin appears in the form of
a yellow, odorless, crystalline powder, forming salts with
metallic oxides.
Solubility.-This drug is sparingly soluble in water
and in alcohol, but forms emulsions with ethereal and
oily fluids, particularly with collodion. It is insoluble
in oils and ether. The alkali salts are easily soluble in
water, giving an orange color.
Therapeutic Applications. Loretin has been pro-
posed as an excellent succedaneum for carbolized water.
It is said to be non-poisonous and to exercise decided
antiseptic powers. It is likewise believed to have some
antithermic virtues. This new drug is reported to have
been of undoubted service, locally applied, in the treat-
ment of wounds, fistulae, and burns, and in that of

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