Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 37

ANTISE PSIN

rhage, for instance-the powder itself or solutions of
the strength of from 40 to 50 per cent. may be used; in
this manner it causes no irritation. In the ocular dis-
eases mentioned 2 per cent. solutions have been em-
ployed; in chronic glaucoma 25 per cent. solutions are
recommended. In otitis 20 per cent., and in cystitis 4
per cent., solutions have been found of marked service.'
ANTISEPSIN.
The common name of antisepsin, also called asepsiz, is
given to the mono- or paramono-brom-plenyl-acet- amid
or paramono-brom-acet-anzilid. Its chemical formula is
CH4BrNHC2H3O.
Physical Properties.-This drug occurs in odorless
and tasteless crystals with a melting-point of 3280 F.
(I64.4 C.).
Solubility.-This remedy is readily soluble in alcohol
and ether, slightly soluble in glycerin, but insoluble in
water.
Physiological Action.-Small doses of antisepsin
cause in the lower animals a fall of the temperature
accompanied with diuresis and increased peristalsis.
Tremors are often also produced. The drug dilates the
pupils. Toxic amounts of antisepsin produce a decided
mydriasis, great reduction of the bodily temperature,
and spasms. There occur also a diminution of the
pulse-gate, and disturbances of the respiration accom-
panied with glycosuria and haemoglobinuria. Death is
caused by respiratory failure.
Therapeutic Applications.-Antisepsin is employed
as an antipyretic, analgesic, and antiseptic. It has given
satisfactory results in cases of typhoid fever, pneumonia,
and phthisis. It has acted favorably in neuralgias. As
1 To a combination in definite proportions of antipyrin, citric acid, and
caffeine, the name of mIgrainin has been applied. It is an antil/,rin-
caffeine citrate, and contains 9 per cent. of caffeine. Migrainin is alleged
to be of value in the treatment of severe cases of migraine. It is given
dissolved in water, in single doses of I5 grains (I gramme).

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