Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 17
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THIS drug is also known under the common name of
hypunonc, but technically it is the p/zenylmethylketone,
having a formula of C 6HCOCH3.
Physical Properties.-Acetophenone is a colorless,
volatile liquid with an odor resembling that of bitter
almonds. It has a sp. gr. of 1.o32, and solidifies at
57.2 F. (14 C.), from which it melts again at 68 F.
Solubility.-Acetophenone is soluble in alcohol,
ether, chloroform, benzin, and oil of sweet almonds, and
insoluble in water and glycerin.
Physiological Action. Upon the lower animals
acetopleno/l' in moderate amounts does not produce
deep sleep; it is said to exert a powerful local paralyzing
influence. Toxic doses cause general muscular paraly-
sis, coma, and death from failure of the respiration.
Therapeutic Applications.-Acetophenone is gener-
ally given in cases of insomnia without pain and in a
variety of nervous disorders. This remedy has a tend-
ency to produce a depressant action, and therefore it
should be carefully watched.
Administration.-Acetophenone is usually adminis-
tered in capsules with oil or in emulsion with syrup or
peppermint-water, in single doses of from I to 5 minims
(o.o66 to 0.3 gramme).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/18/: accessed November 24, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.