Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 18
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18 NOTES ON THE NE WER REMEDIES.
This recent antipyretic, also called aceto-ortho-toluide,
is represented by the formula C7H,.NH.C2H30.
Physical Properties.--Acet-toluide appears in the form
of colorless needles having a melting-point of 224.60 F.
(107 C.) and a boiling-point of 564.8 F. (2960 C.).
Solubility.-Aceto-ortho-toluide is soluble in alcohol,
ether, and hot water; less so in cold water.
Therapeutic Applications.-Resembling acetanilid
and methyl-acetanilid in their action, acet-toluide is said
to be a powerful antipyretic. While it reduces the tem-
perature very decidedly, it is claimed to be less toxic
than the other two remedies mentioned. This new anti-
pyretic has been employed in febrile disorders with
apparent satisfactory results, but the dosage has not
been accurately determined.
An alkaloid principle extracted from the common
aconite, or monk's-hood, Aconitum napellus.' Accord-
ing to the most recent investigations, the chemical
composition of aconitine, also called benzoylaconine, is
Solubility.-Most of the salts of aconitine are soluble
Physiological Action.-Aconitine is a local anaes-
Circulation.-This drug is a cardiac depressant, lower-
ing the blood-pressure and the pulse by a direct action
on the heart-muscle. Experimentally, it exercises no
apparent vaso-motor influence. Poisonous amounts pro-
duce marked diminution of the pulse-rate, preceded
sometimes by an increase as the result of heart-weak-
1 Monk's-hood contains other principles, such as aconine (C,22-35NO9),
pseudoaconine (CZI 41NO8), pseudoaconitine or veratro'laconine (C36H49-
NO,,), and piclraconitine (CsH39NO10). All these substances, however,
have not been tried in practical medicine.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/19/: accessed May 23, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.