Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 24
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NOTES ON THE NE WER REMEDIES.
The technical name of this substance is dimethylethyl-
carbinol. It is a tertiary alcohol, and is represented by
the formula (CH3)2C2H5COH, or C5H120.
Physical Properties.-Amylenchydrate is a colorless
thick liquid having a peculiar penetrating odor. It is
hygroscopic, has a sp. gr. of 0.8 I, and when pure it boils
at 216.20 F. (IO2.5 C.).
Solubility.-This drug is soluble in 8 parts of
water at 590 F. (150 C.), the solution becoming turbid
when warmed. It mixes with alcohol, ether, and chloro-
Physiological Action.-Nervous System.-Upon the
lower animals small quantities of amylenehydrate cause
deep sleep without disturbing the circulation or the
respiration. Large or toxic amounts are said to paralyze
the medulla oblongata.
Metabolism.-Unlike chloral, the drug under consider-
ation diminishes tissue-waste.
Therapeutic Applications. Amylenehydrate is a
valuable hypnotic, standing, in its effects, midway
between chloral and paraldehyde, and it is usually free
from the unpleasant effects often produced by the
latter two drugs. This remedy is employed in insom-
nias not due to pain, and especially in those resulting
from the withdrawal of other narcotics previously used.
It is likewise valuable in whooping-cough of children.
The sleep produced by amylenehydrate is quiet and
refreshing. As a hypnotic, judging from its action on
metabolism, it is to be preferred to other similar reme-
dies, especially in those diseases that are accompanied
by great nitrogenous waste.
Administration.-This remedy is given in single doses
of from I to 2 drachms (4 to 8 grammes), in capsules by
the mouth or by the rectum. For children the quantity
of this drug employed should not exceed 3 or 4 minims
(o.oi8 to 0.025 gramme).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/23/: accessed March 17, 2018), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.