Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 28
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28 NOTES ON THE NE WER REMEDIES.
Solubility.-Anticylic acid is readily soluble in water,
alcohol, and glycerin.
Therapeutic Applications.-This remedy is said to
be antipyretic, and has been found of service in pneu-
monia, enteric fever, and acute articular rheumatism.
Administration.-The dose of anticylic acid is set
down as 1 0 of a grain (0.00ooo6 gramme).
The proper term for this drug is acetanilid or phenyl-
acetamid, antifebrin being its original patent name. It
is an anilin in which one atom of hydrogen has been
replaced by the radical acetyl. Its chemical composition
is C6H5NHC,H,O, or C8sHNO.
Physical Properties.-Antifebrin is a colorless and
tasteless crystalline substance, and when pure it occurs
in brilliant rhombic tables. The crystals melt at 2350 F.
(I 12.80 C.) and boil at 557.6 F. (2920 C.). It is broken
up into its original compounds by the prolonged action
of hydrochloric acid.
Solubility.-Antifebrin is readily soluble in ether
and chloroform; in cold alcohol in the proportion of I
part to 3 ' parts; freely in boiling alcohol; and also in
benzene and alcoholic liquors. It is insoluble in water
at ordinary temperatures.
amounts of this drug produce no changes in the circula-
tion. The blood is considerably altered under large
doses: it becomes brownish red, its ozonizing power is
diminished, its alkalinity decreased, and finally its haEmo-
globin is changed into methemoglobin. Accompanying
this phenomenon there is a destruction of the corpuscular
elements. The heart, though apparently stimulated at
first, is depressed, especially by large doses, and is finally
arrested in diastole. The action on the pulse is irregu-
lar, although it is generally depressed also. Small
quantities increase, and large quantities lower, arterial
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/27/: accessed March 30, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.