Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 30
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30 NOTES ON THE NE WER REMEDIES.
reduction of the abnormal temperature. On account of
its decided action on the blood, the use of the drug is
contraindicated in anemic individuals. The power of
antifebrin as a sedative and an analgesic is quite marked;
hence its usefulness in mania, epilepsy, ataxia, sciatica,
whooping-cough, migraine, and chorea. This agent has
given great relief in the laryngeal spasms of tabetic
patients. As a hemostatic it has rendered good service
in epistaxis and haemoptysis, and as an antiarthritic in
rheumatic affections. It has also been recommended as
a local antiseptic, as an excellent application in obstinate
ulcers, and similarly in the treatment of skin diseases,
such as psoriasis, eczema, erysipelas, urticaria, etc.
Administration.-Antifebrin is given to adults in
doses of from 5 to Io grains (0.3 to o.6 gramme), or as
high as 30 grains (2 grammes) in the course of the day.
It is best administered in capsules or wafers, or, espe-
cially in the case of children, in mucilage of acacia. As
a local remedy, an ointment with vaseline in the strength
of 20 grains to the ounce (I.3 in 30 grammes) may be
employed, either by itself or as an adjunct to mercurial
Toxicology.-Though death has rarely been produced
by antifebrin, even when administered in comparatively
large amounts, yet this agent is apt to cause alarming
symptoms. Among the untoward effects produced by
antifebrin may be mentioned hallucinations in weak
constitutions, delirium, dizziness, pain over the stomach,
diarrhea, hemorrhages, palpitation, profuse sweating,
rigors, marked cyanosis, muscular twitchings, rigidity,
and clonic convulsions. In acute poisoning a slow, com-
pressible pulse, a shallow respiration, cyanosis, and pro-
fuse sweating are the chief symptoms noticed. The
prolonged use of the drug may give rise to congestion
of the various organs and to the formation of heart-clots.
No exanthematous rash has been observed from the
action of antifebrin. In cases of acute poisoning by
this drug cardiac and respiratory stimulation by digitalis
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/29/: accessed April 27, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.