Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 32
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32 NOTES ON THE NE WER REMEDIES.
crystalline powder, odorless, and of a somewhat bitter
taste, having a melting-point of 235.40 F. (i 30 C.).
This drug can be differentiated from other organic sub-
stances by its characteristic reaction with the perchloride
of iron. With the latter body antipyrin gives a dark-
red coloration. With nitrous acid or the nitrates it
exhibits an emerald-green color with the formation of
isonitroso-antipyrin, and with nitric acid a yellow hue is
produced, this latter color turning to crimson on the
application of heat.
Solubility.-Antipyrin is readily soluble in water,
rectified spirit, and chloroform, and in ether in the pro-
portion of I part to 50 parts.
Incompatibility.-Antipyrin is incompatible with
quite a number of substances. It is precipitated from
an aqueous solution by the following: carbolic acid, the
chlorides of mercury, cinchona-bark, infusion of catechu,
tannin, uva ursi, and the tinctures of hamamelis, iodine,
kino, and rhubarb. This drug is also incompatible with
nitrous compounds, especially sweet spirit of nitre, cal-
omel (with which a poisonous compound is formed),
beta-naphthol, chloral, bicarbonate of sodium, the salts
of quinine, and caffeine.
Physiological Action.--Nervous System--In the
lower animals small doses cause excitation of the brain,
medulla oblongata, and spinal cord, accompanied with
an increase of reflex action. Severe epileptiform and
tetanic convulsions are soon afterward developed, but
consciousness remains intact. The convulsions are
chiefly of cerebral origin. These symptoms are suc-
ceeded by those bf paralysis, especially under large
quantities of the drug, followed by a total loss of reflex
action. The latter phenomena are the result mainly of
an action of antipyrin on the spinal receptive centres
and on both the sensory and motor nerve-trunks. The
action on the sensory nerves appears to be more pro-
nounced than that on the motor fibres.
Muscular System.-Large amounts of antipyrin pro-
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/31/: accessed April 25, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.