Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 33
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duce rigidity of the muscles, due to a direct action on
the muscular fibre. The irritability of the muscles is
ultimately diminished, and even destroyed, especially
when the drug is applied locally.
Circulation : The Blood.-Therapeutic doses of anti-
pyrin exercise no action upon this tissue. This drug is
a hemostatic, hence it is said to be more powerful than
the salts of iron or even of ergotin. Large, and partic-
ularly toxic, amounts of antipyrin cause a chocolate
color of the blood (cyanosis), owing to an alteration of
the hemoglobin into methaemoglobin. Besides this
transformation antipyrin causes a diminution of the
respiratory capacity of the blood, and even destruction
of the corpuscular elements. It is said that these alter-
ations bear some relation to the period and extent of
the antipyretic action, and that the fixation of oxygen
by the haemoglobin is only produced by doses which
cause a depression of the temperature amounting to I,
2, and 30 C.
Blood-pressure.-Small and moderate amounts of anti-
pyrin produce a rise of the arterial pressure from a
direct cardiac action. Large and toxic quantities cause
a decided fall of the pressure, due to a direct depressant
action upon the heart itself. The vaso-motor system is
apparently not influenced by the drug.
The Pulse.-This remedy causes an increase of the
pulse-rate through paralysis of the cardio-inhibitory
centres, followed by a diminution in the number of
pulsations, this phenomenon being dependent upon a
depressant action of the drug on the heart itself.
Respiration.-Moderate doses of antipyrin produce an
increase in the number of respiatory movements, owing
to a direct action on the centres of the medulla oblon-
gata. Ultimately the rate of respiration becomes de-
pressed, and by failure of this function death often is
Temperature.-Antipyrin in therapeutic amounts exer-
cises no action on the normal heat-functions. In fever,
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/32/: accessed June 22, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.