Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 34
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34 NOTES ON THE NEWER REMEDIES.
however, the drug causes a decided fall of the bodily
temperature, this reduction being due to a great increase
in heat-dissipation together with a fall of heat-produc-
tion. This phenomenon is effected chiefly through a
Metabolism.-The drug diminishes the amount of
urine excreted, this fluid remaining normal, but exhibit-
ing a darkish color. At the same time this remedy
causes a diminution in the elimination of the products
of nitrogenous tissue-metamorphosis. It is said to in-
crease also the amount of sulphuric acid in the urine.
Elimination.-This drug is rapidly eliminated by the
urine, in which this remedy may be detected in from
three to four hours after its ingestion by the stomach.
It is claimed that this agent is likewise partly eliminated
by the saliva.
Dzgestive Tract.-Moderate amounts of antipyrin
exercise no influence either on the secretion of the gas-
tric juice or upon the mechanism of digestion. Anti-
pyrin often produces vomiting, this action being of
Antiseptic Action.-Antipyrin, even in small doses,
appears to exercise an antiseptic influence. In large
amounts this medicament not only delays fermentation,
but it likewise stops the development of, and even
destroys, lower organisms.
Therapeutic Applications.-Antipyrin has been, and
is, used in so large a variety of diseases with alleged
success that it seems as if this agent were regarded as a
panacea. The remedy is distinctly valuable as a general
antipyretic and analgesic. It has rendered good service
in acute fevers like typhoid and typhus, in acute rheu-
matism, in erysipelas, and in tubercular diseases. This
drug has been employed with apparently good results in
malarial fever, especially when the hyperpyrexia is per-
sistent, and even in pneumonia. In these instances,
however, and particularly in asthenic fevers and in pneu-
monia, this remedy is to be given with extreme caution
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/33/: accessed June 23, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.