Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 36
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36 NOTES ON THE NEWER REMEDIES.
may be mentioned nausea and vomiting and'a peculiar
erythematous eruption which may resemble measles,
scarlatina, urticaria, or pemphigus. The rash is fre-
quently accompanied with a troublesome pruritus, facial
cedema, coryza, laryngitis, and catarrhal conjunctivitis.
The eruption usually lasts from three to seven days or
longer, appearing about the extremities and trunk and
finally extending all over the body. The appearance of
bulla has also been noticed. Nervous symptoms, such
as languor, giddiness, somnolence, and coma which may
pass into deep stertorous unconsciousness, are produced;
at other times cerebral excitement, tremblings, and hys-
terical manifestations are noticed. A cyanotic condition
of the hands, face, nose, and lips, accompanied with cold
extremities and a weak, rapid pulse, is often seen.
Tingling sensations, profuse sweating, and collapse are
also symptoms frequently observed. All these untoward
effects appear to be more frequent in women than in
men, in adults than in young subjects, and are generally
produced by moderate doses of antipyrin. In chronic
poisoning resulting from prolonged use of the drug
there have been observed after death marked congestion
of the brain and membranes with exudation into the
ventricles, inflammation of the kidneys, contraction of
the spleen, congestion of the lungs, and disintegration
of the corpuscular elements of the blood. In acute
poisoning by antipyrin general stimulation should be
resorted to with the external application of heat." The
administration of digitalis, strychnine, and caffeine is
indicated, and inhalations of oxygen may be tried for
the relief of the cyanosis.
Administration.-Antipyrin may be given in single
amounts of from 5 to 30 grains (0o.3 to 2 grammes) for
adults. For children 3 grains (o.I9 gramme) at a dose,
once or twice daily, are sufficient, administered in pep-
permint-water or in syrup of orange-peel to disguise the
taste of the drug. This remedy can also be employed
hypodermatically. As a local application-as in hemor-
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/35/: accessed April 29, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.