Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 39
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AN TI THE R MIN.
Physiological Action.-Antispasmin in doses of from
) of a grain to I0 grains (o.oI to o.Io gramme) is said
to produce a marked narcotic effect. It causes fatal
effects in rabbits in quantities of 7 i2 grains (0.5 gramme)
per kilo of the body-weight.
Therapeutic Applications.-This new combination
has been found effective as an excellent sedative and
hypnotic, and is particularly indicated in spasmodic affec-
tions associated with pains. Thus, it has been found
useful in convulsive cough, stridulous laryngitis, and
whooping-cough. In the latter disorder this remedy is
asserted to act on the branches of the superior laryngeal
nerve, diminishing in this manner the reflex excitation
of the larynx.
Administration.-Antispasmin is best administered in
solution in sweetened water. The dose is put down as
from - of a grain to I I grains (o.oi to o.Io gramme),
and even as high as 3 grains (0.20 gramme).
The chemical name of this drug is phenyl-hydrazin-
levulinic acid, it being a substance allied to antipyrin.
It is obtained by the interaction of phenylhydrazin and
acetopropionic acid, and is represented by the formula
CH5NHC-(C H)-C HCOOH.
Physical Properties.-This remedy occurs in color-
less crystals which melt at about 226 F. (lo80 C.).
Solubility.-This drug is soluble in hot alcohol and
in ether, but is insoluble in water.
Physiological Action.-It is affirmed that antithermin
intravenously injected into the lower animals causes a
diminution in the rate of the pulse, the arterial pressure
remaining unaltered. The drug reduces the bodily tem-
perature, and there occurs a decrease both of heat-pro-
duction and heat-distribution.
Therapeutic Applications.-Antithermin is used as
an antipyretic in those febrile affections for which anti--
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/38/: accessed October 21, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.