Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 40
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40 NOTES ON THE NEWER RE MEDIES.
pyrin is employed, but its power is apparently weaker
than that of the latter remedy.
Administration.-The dose of antithermin is about 5
grains (0o.3 gramme), and it is best administered in alco-
holic solutions or in wafers.
Toxicology.-This drug is apt to cause untoward
effects such as heaviness in the head, pallor of the face,
and perspiration. Its ingestion, especially in debilitated
individuals, should be made with caution.
This body is contained, in combination with other
substances, in the fruit of the common parsley, Petrose-
linum sativzlm or Caruym petroselinuzm. Its formula is
Physical Properties.-This drug occurs in long white
needles with a faint parsley odor. It melts at 860 F.
(300 C.) and boils at 561.2 F. (294 C.); its sp. gr. is
Solubility.-Apiol dissolves readily in alcohol and
ether, but is insoluble in water.
Therapeutic Applications.-This remedy has been
used with apparent success in the treatment of dysmenor-
rhcea, and is also said to have given good results as an
antiperiodic against malarial disorders.
Administration.-Apiol (this substance must not be
confounded with the alcoholic liquid extract obtained
from parsley-seeds) may be given in doses of from Io to
15 grains (o.65 to I gramme), and it is best administered
Toxicology.-Large doses of apiol are said to cause
intoxication with ringing in the ears and severe frontal
This drug is said to be prepared in the same manner
as apomorphine. The salt of apocodeine generally used
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/39/: accessed May 23, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.