Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 45
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ASPID OSPE RINE.
crystalline body, but the quite recent combination aspar-
agin hydrargyrate, in 2 per cent. solution, is a colorless,
limpid liquid having a sharp metallic and acrid taste.
Therapeutic Applications.-Asparagin has diuretic
properties, and has been used with asserted success for
the purpose of increasing the activity of the kidneys.
The hydrargyrate has of late been tried, with alleged
excellent results, as an antisyphilitic.
Administration.-Hydragyrate of asparagin is ad-
ministered hypodermatically in single doses of ( of a
grain (o.oi gramme).
The name of Aspidospermine is given to an alkaloid
obtained from the bark of the quebracho plant, or Aspi-
dosperma quebracho. This principle has the composition
C,,2 H3O 0N22
Physical Properties.-Aspidospermine occurs in pris-
matic colorless crystals.
Solubility.-This alkaloid is soluble in 48 parts of
alcohol and in Io6 parts of ether. It is insoluble in
Physiological Action.-This drug very distinctly
increases the respiratory movements. It lowers the
temperature and slows the action of the heart.
Therapeutic Applications.-This drug has been em-
ployed with apparent success in affections of the respi-
ratory tract, such as asthma, dyspncea, etc.
Administration.-Aspidospermine is given in doses
of from '4 to I grain (o.o16 to 0.03 gramme). It may
also be administered hypodermatically from a solution of
the strength of I grain to I drachm of water (o.o6 in 3.9
grammes). This solution must be kept as such by the
addition of a little sulphuric acid. At the time of the
injection the acid can be neutralized by a little bicarbon-
ate of sodium. The hypodermatic dose of this solution
is 15 drops (0.92 cc.).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/44/: accessed March 30, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.