Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 48
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NOTES ON THE NE WER REMEDIES.
chemically represented by the formula C9,H.OCH,.-
Physical Properties.-Benz-analgen occurs in the
form of tasteless, colorless crystals having a melting-
point of 406.40 F. (208 C.). The drug leaves no resi-
due on being heated upon platinum wire.
Solubility.-This drug is readily soluble in hot alco-
hol and in dilute acids, slightly soluble in cold alcohol,
and scarcely so in water.
Physiological Action.-Benz-analgen is dissolved by
the gastric juice, and appears in the urine in from half
an hour to an hour after its ingestion by the stomach.
It is broken up in the stomach into benzoic acid and
ortho-oxyethyl-ana-amido-chinolin, the presence of the
latter body in the urine being shown by a reddish tint,
as in the case of analgen.
Therapeutic Applications.-Like analgen, the benzoyl
compound has antiseptic properties, and also the power
of dissolving uric acid. It produces antithermic and
antineuralgic effects similar to those of phenacetin and
superior to those of analgen. It has been observed that
the reduction of the temperature (in phthisical patients
especially) by benz-analgen is accompanied by profuse
sweating, but without other disagreeable effects. This
drug has been found quite effective in cephalalgias and
essential neuralgias. It is affirmed to be of service also
in muscular rheumatism, in tabes, and in chronic gout.
In all these latter disorders it has been efficacious in
Administration.-Benz-analgen may be given in daily
quantities of from 7 2 to 45 grains (0.5 to 3 grammes),
or even as high as 75 grains (5 grammes).
This compound, named likewise phenyl-benzamid and
benzoyl-anilid, has a chemical formula of CH,,NH,CO,-
CH,. It is obtained from the interaction of benzoic
anhydride or benzoyl chloride and anilin, and bears the
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/47/: accessed June 25, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.