Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 53
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BOLDOA FRAGRANS.-BROMAL HYDRATE.
Administration.-The average dose of this substance
is put down as from 6o to 75 grains (4 to 5 grammes) a
Recent investigations have pointed to the existence in
this plant of a glucoside termed boldin,' the chemical
nature of which still remains unknown.
Therapeutic Applications.-The active principle, or
boldin, is said to act as a local anaesthetic. A tincture
of the plant has been employed with asserted success as
a diuretic in diseases of the liver and in rheumatism.
Administration.-The tincture of boldoa is given in
doses of from to to 15 minims (o.6 to I gramme).
Bromal hydrate is analogous to chloral hydrate. It
is obtained by the action of bromine upon alcohol. The
alcohol, by losing two atoms of hydrogen, is first con-
verted into aldehyde, and the other three atoms are then
replaced by the bromine. Its formula is C2HBr3O,H20.
Physical Properties. This drug occurs in the form
of a white crystalline substance with a pungent taste and
an odor resembling that of chloral.
Solubility.-Hydrate of bromal is soluble in water,
but somewhat less so than chloral.
Physiological Action.-Small doses cause in the lower
animals restlessness, contraction of pupil, increased secre-
tion of the buccal and nasal mucous membrane, and
respiratory stimulation followed by a decrease of the
same. This drug acts upon the heart-muscle directly
and more powerfully than does chloral. It is also a
powerful stimulant to the excito-motor centres. These
effects are aggravated under large quantities of bromal
hydrate, and death, which occurs from respiratory failure,
is preceded by convulsions and anesthesia.
1 Boldoa chiliensis is also said to yield a principle termed boldin, which
has been used in biliary calculi and as a hypnotic in doses of 3 grains
(0.25 gramme) a day, administered in capsules.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/52/: accessed September 20, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.