Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 61
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Therapeutic Applications.-Both principles have
been used as hypnotics, but cannabine is said to be espe-
cially valuable in acute mania and nervous insomnia.
Administration.-The daily dose of cannabine is fi-om
I to 5 grains (o.o6 to 0.30 gramme). The tannate may
be given in doses of from 2 to io grains (0.13 to o.6o
This body is the non-alkaloidal active principle ob-
tained from several species of the Spanish fly. or beetle,
coleopterous insects, especially the Cantharis vesicatoria.
Cant/zaridin is represented as having the composition
Physical Properties.-This new agent occurs as a
colorless crystalline substance made up of four-sided
Solubility.-Cantharidin is readily taken up by chloro-
form, ether, and the fatty oils. It is slightly soluble in
alcohol, but is insoluble in water.
Physiological Action.-It has been asserted that this
drug produces in inflammatory processes a transudation
of sanguineous microbicidal serum, but this has been
denied, since no such results have been obtained in
experiments performed upon the lover animals.
Therapeutic Applications.-This remedy has of late
been applied, hypodermatically injected, in the treatment
of tuberculosis, but the value of this medicament has
not yet been accurately determined. The results so far
obtained have not been very satisfactory.
Administration.-The dose of cantharidin has not yet
1 The cantharidale of cocaine is a combination recently introduced into
practical medicine. It is a mixture of cantharida/e (f sodizium and I in Ioo
of hydrochlorate of cocaine. This new compound occurs in the form of a
white, inodorous, amorphous powder with a sharp taste, readily soluble in
alcohol, ether, benzene, and hot water. It has been employed with alleged
happy results in the treatment of tubercular disease. Administered sub-
cutaneously, this remedy is said to be absolutely painless. The single dose
is about Td of a grain (o.ooo6 gramme).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/60/: accessed May 24, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.