Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 63
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CAR VA CROL.- CASCA RINE.
ployed by the mouth in daily amounts of s of a grain
(0.025 gramme), but it is said not to be so effective when
given in this manner.
This substance, said to be a phenol, is contained in the
essential oil of the Origanum species. The chemical
composition of carzvacrol is C12H40O.
Physical Properties.-Carvacrol occurs as a thick
oily body with a melting-point of 451.40 to 4550 F.
(233 to 235 C.). Iodide of carvacrol is a yellowish-
Solubility.-This salt is freely soluble in chloroform,
ether, and olive oil; it is insoluble in water.
Therapeutic Applications.-Carvacrol has only been
used locally as an antiseptic in diseases of the skin, and
in the treatment of wounds and ulcers as a substitute for
Administration.-This drug has been employed in
the form of powder, ointment, or gauze.
Cascara sagrada (sacred bark) is the Spanish name
given to the bark of the Rhamnus purskiana.
Therapeutic Applications.-Cascara is most valuable
as a tonic and laxative, especially in the treatment of
habitual constipation. (See Cascarine.)
Administration.-The dose of the fluid extract, best
given after meals, is from 10 to 15 minims (0.6 to o.9
This is said to be the active principle of Cascara
sagrada, from which it has recently been isolated. Later
studies have apparently shown that cascarine is identical
with r/zamno-xantine, occurring in the buckthorn, or
Rhamnus frangula. Cascarine is said to be composed
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/62/: accessed May 24, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.