Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 64
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64 NOTES ON THE NE WER REMEDIES.
Physical Properties.-This new principle occurs as a
fine crystalline, tasteless, and odorless powder .having a
melting-point of 3920 F. (200 C.). Some specimens of
cascarine are red, others yellow, and still others orange-
yellow, the coloration depending upon the degree of
Solubility.-Cascarine is soluble in alcohol, chloro-
form, and alkaline fluids. With the latter it produces a
purple-red solution; with alcohol it gives a yellow hue.
This drug is slightly soluble in ether, but insoluble in
Therapeutic Applications.-This remedy is, like its
mother-drug, serviceable in habitual constipation. Intra-
venous injections of cascarine are said to have produced
bilious non-diarrhceal stools.
Administration.-Cascarine may be administered in
the form of pills, in daily doses of from I2 to 3 grains
(o.Io to 0.20 gramme), best given before meals.
Species of Cassia yield an active principle known as
Physical Properties.-This drug occurs in brown
Solubility.-Cathartinic acid is readily dissolved by
water and alcohol.
Therapeutic Applications.-This remedy, apparently
destitute of poisonous properties, is employed simply as
Administration.-Cathartinic acid may be adminis-
tered in doses of from 4 to 6 grains (0.26 to 0.39 gramme).
This alkaloid has been extracted from the Celastrus
edtulis, but its chemical composition has not been studied
Physiological Action.-Ncrvous System.-In cold-
blooded animals celastrine causes excitement at first,
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/63/: accessed October 22, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.