Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 65
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followed by depression. In small amounts it is a decided
stimulant to the nervous system. Similar effects are
produced on warm-blooded animals.
Circulation.-On the heart of the frog the drug acts
as an excitant, producing an increase in the number of
pulsations. The same effect is observed in higher ani-
mals like the dog. The blood-pressule is not affected
by therapeutic doses, but it is diminished under large
Respiration.-Celastrine produces an increase in the
depth of the respiration, but a diminution in the fre-
quency of the movements; these effects are accompanied
by marked restlessness of the animal.
Temperature.-This drug causes a rise of the bodily
Pupil.-Under the action of the medicament the pupil
On the whole, celastrine resembles cocaine in its
action, producing general excitement, stimulation of the
brain, and great increase of the bodily temperature; but,
unlike cocaine, celastrine does not abolish sensibility nor
does it produce convulsions. The action of this drug
on the cord, the vagi, and the heart is much less pro-
nounced than that of cocaine.
Therapeutic Applications. Although not yet suffi-
ciently tried, celastrine has been found, as already inti-
mated, to have properties similar to those of cocaine.
The plant itself is said to possess marked aphrodisiac
virtues, but the native Arabs use the drug chiefly to
enable them to support hunger and fatigue.
Cetrarine is the principle obtained from the common
Iceland moss or lichen (Cctraria islandica), and has a
formula of C18H1608.
Physical Properties.-Cetrarine occurs in white crys-
talline acicular needles having a bitter taste.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/64/: accessed February 22, 2018), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.