Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 67
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CHL ORAL AMID.
This substance is trichlor-amido-ethylic alcohol, with a
formula of CCl,CH,OH,NH,, or, better, CC13.COH.NH3.
Physical Properties.-This drug occurs as a white
crystalline powder having a melting-point of 1470 F.
Solubility.-C/oral ammonium is soluble in alcohol,
and slightly so in water.
Therapeutic Applications.-This remedy is used
chiefly as'an analgesic and hypnotic in a variety of dis-
orders characterized by wakeful nervous insomnia.
Administration.-The dose of chloral ammonium is
from 15 to 30 grains (I to 2 grammes).
This drug is also termed chloral-formamid, and is
obtained from the interaction of formamid and chloral.
Its formula is given as CC/CH NCHO
Physical Properties.-Chloralamid is a crystalline
and slightly bitter substance with a melting-point of
2390 F. ( 1 5 C.).
Solubility.-This drug is soluble in alcohol, and in
water in the proportion of I to 9 parts.
Physiological Action.-Local Action.-Chloralamid
has a slight local action, and in large amounts tends to
produce mucous diarrhoea.
Nervous Systcm.-This drug acts more powerfully
upon the cerebral cortex than upon any other portion
of the nervous system of voluntary life, thereby causing
sleep and muscular relaxation, but it is also a feeble
spinal depressant. The reflexes are abolished and the
conductivity of the motor nerves is destroyed under
sufficiently large amounts.
Circulation.-The influence of this drug upon the
circulation is a feeble one, the changes produced by
small doses being probably secondary to other effects of
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/66/: accessed November 19, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.