Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 68
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68 NOTES ONA THE N'EWER REMEDIES.
the drug; toxic doses, however, depress arterial pressure
by a direct action upon the heart or upon the muscle-
coats of the arterioles. The pulse-rate is diminished by
Respiration.-Chloralamid in moderate doses has a
powerful influence upon the respiration by a centric
action stimulating the respiratory rate, and probably also
by increasing the actual amount of air breathed, but in
toxic doses it depresses this function, and finally kills by
lIetabolism.--The excretion of urea is increased by
small doses, but is diminished by large ones. The
excretion of phosphates appears to be decreased both by
large and by small doses of the drug.
Urine.-Small amounts have no apparent effect upon
the renal function, but large doses diminish the excretion
of the fluid constituents of the urine.
Therapeutic Applications.-Chloralamid is used
advantageously as a hypnotic in a large variety of ner-
vous disorders, and in this respect it is considered safer
than, and superior to, chloral, especially in the sleepless-
ness occurring in cardiac affections. This drug produces
sleep in from half an hour to forty-five minutes after its
ingestion, the sleep lasting from five to eight hours.
This remedy has given excellent results in nervous
insomnia, in neuralgia, and even in tabes dorsalis.
Chloralamid not only causes sleep, but also relieves
pain. Recently this medicament has been found of
great service, particularly when combined with bromide
of potassium, in the treatment of seasickness.
Administration.-This drug is best given in water, in
doses of from 30 to 50 grains (2 to 3.5 grammes).
Toxicology. No fatal results from the use of chlo-
ralamid have been reported, yet untoward effects con-
sisting of skin-eruptions have been observed, these dis-
appearing on discontinuing the employment of the
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/67/: accessed April 26, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.