Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 69
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CHL ORA L-CAF FEINE.-- CHL ORAL OSE.
This new preparation is said to be a molecular com-
bination of the two drugs chloral and caffeine, and is
represented by the formula CsH1oN402.CCI2CH : O.
Physical Properties.- Chloral-caffeine occurs in the
form of white shining leaflets.
Solubility.-This drug is readily soluble in cold water.
Incompatibility.-Alkalies decompose the combina-
tion into chloroform and caffeine.
Therapeutic Applications.-This remedy has been
found of great value in the treatment of rheumatic affec-
tions such as sciatica. It is said to have relieved violent
asthmatic attacks. Observers claim that this medica-
ment is of particular service in cases of irritation of the
peripheral nervous system. The subcutaneous use of
this drug is asserted to be painless.
Administration.-Chloral-caffeine has been employed
hypodermatically in doses of from 3 to 4'2 grains (0.2
to 0.3 gramme) each, or in daily amounts of from 6 to
13Y2 grains (0.4 to 0.9 gramme).
Clloralose is the name given to a recent derivative of
chloral obtained by heating the latter substance with
glucose. Chloralose with sulphuric acid gives a di-sul-
phuric compound, and with acetic anhydride a compound
containing four acetyl groups. The formula of this new
substance is said to be C8H,,C130O.
Physical Properties.-Chloralose occurs in the form
of fine needles which volatilize completely without de-
Physiological Action.-This drug causes sleep in
birds, cats, and dogs, as well as in man; it has the
advantage over chloral of not depressing the spinal cord.
This new remedy acts also as an analgesic.
Therapeutic Applications.-Chloralose has been
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/68/: accessed August 20, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.