Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 72
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72 NOTES ON THE NEWER. R REMEDIES.
Therapeutic Applications.-The fresh leaves of the
plant furnish a juice which is claimed to be beneficial in
the treatment of cataract without operation.
Administration.-The juice is simply dropped into
the eye, in doses of 2 minims (o.15 gramme) three times
This new combination of cocaine contains about 75
per cent. of the alkaloid.
Physical Properties.- Cocaile plc;natc occurs as a
viscid yellowish mass.
Solubility.-This new medicament is soluble in alco-
hol, but insoluble in water.
Therapeutic Applications.-This drug is employed
as a local anaesthetic in catarrhal affections of the nose
and stomach and in other disorders.
Administration.-Cocaine phenate may be given in-
ternally, in capsules, in doses of from 1 to of a grain
(o.oo5 to o.oI gramme). It may also be used by insuffla-
tion. For local application the strength of the solutions
may vary from 5 to Io per cent.
This alkaloid is represented by the formula C1sH21NO3.
The new salt, the phosphate, is represented by the formula
C1sH21N03-H3P03, I4 2Aq.
Physical Properties.-The alkaloid occurs in color-
less bitter crystals with a melting-point of 302 F. (1 500
C.). The phosphate of codezine appears in white needles
which are also of a bitter taste.
Solubility.-Codeine is readily soluble in alcohol and
ether, and in boiling water in the proportion of I to 17
parts. Codeine phosphate is soluble in water, and slightly
so in alcohol.
Physiological Action.-The action of codeine is
similar to that of morphine. As a narcotic codeine is
less powerful than its sister alkaloid, and in large quan-
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/71/: accessed October 23, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.