Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 73
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tities causes tetanus more fi-equently than does morphine.
Codeine paralyzes the peripheral motor nerves. The
pulse, blood-pressure, and respiration are not affected
except by toxic doses. This drug exercises no dele-
terious action on the alimentary tract.
Therapeutic Applications.-Codeine has been highly
recommended as an excellent nervous sedative. It has
been employed with advantage in bronchitis and in all
kinds of irritating cough, as that of phthisical patients.
It has been lauded as having a special value in diabetes
mellitus. The salt here referred to is said to possess
special advantages in mental disorders, and to have given
excellent results in the treatment of morphinism.
Administration.-The dose of the alkaloid or of the
salt is put down as from I 2 to 2 grains (o.o9 to 0.I2
By a process of hydrolysis colchicine yields a substance
which has been termed colchiccine, having a chemical
composition of C2IH,,(OH)NO,.
Solubility.-Colchiceine is readily soluble in boiling
water, alcohol, and chloroform, and slightly soluble in
Physiological Action. The action of this substance
has not been accurately ascertained, but it is said to
behave very much like colchicine, causing, in sufficiently
large quantities, vomiting and severe purging with tenes-
mus, and a rapid pulse at first, followed by a decrease of
cardiac rate, and finally by heart-paralysis. Death occurs
without convulsive phenomena. The urine seems to be
at first increased and afterward diminished in amount.
Therapeutic Applications.-This drug has been
mainly employed, with alleged success, in the treatment
of acute rheumatism and gout.
Administration.-Colchiceine is best given hypoder-
matically in doses of from W to of a grain (o.ooi to
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/72/: accessed September 23, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.