Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 74
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74 NOTES ON THE NEWER 'REMEDII'S.
Colchicine is the active principle of the common
meadow-saffron (Colchicum autumnale), its formula being
Physical Properties.-This drug occurs as an amor-
phous body with a melting-point of from 289.40 to
296.60 F. (143 to 147 C.).
Solubility.-Colchicine is readily soluble in water,
alcohol, and chloroform.
Physiological Action.-This alkaloid resembles the
mother-drug in its action. It is a violent gastro-intes-
tinal irritant, poisonous doses producing great prostra-
tion, vomiting, and severe purging. This drug causes a
period of excitement accompanied by convulsions with
greatly increased reflexes, followed by abolition of reflex
actions and paralysis. The higher nerve-centres, like
the cord and the peripheral sensory nerves, are decidedly
affected by the drug, but the motor nerves as well as the
muscles remain intact. Upon the circulation, the respi-
ration, and the temperature the drug exercises, in mod-
erate amounts, little or no influence.
Therapeutic Applications.-Like colchiceine, the
remedy under consideration has been employed in the
treatment of rheumatism and gout, with alleged success.
It is also recommended in sciatica.
Administration.-The dose of colchicine varies from
rh to 0 of a grain (0.0005 to 0.003 gramme).
The bark of Gonzobolus condurango is said to contain a
glucoside and other active principles.
Therapeutic Applications. Condurango is mostly
used as an alterative in syphilis and cancer. It is also
effective as a stomachic tonic.
Administration.-The only preparation used at
present is the fluid extract, the dose of which is from
20 to 30 minims (1.2 to 2 grammes).
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/73/: accessed February 16, 2019), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.