Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 75
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COANESSINE.-CONIINE IIYDROBR OMA TE.
From the bark of the two plants Holarrhena africana
and HolarrhcLna anltidyscnterica has been extracted an
alkaloid termed concssine, the chemical composition of
which is put down as C2 4,,N2.
Physical Properties.- Conessine appears as a crystal-
line acicular substance with a melting-point of 249.8 F.
Solubility.-Conessine is freely soluble in alcohol,
chloroform, and ether. Water dissolves it with difficulty.
Therapeutic Applications.-This drug appears to be
of service in the treatment of diarrhcea and dysentery,
but its therapeutic value in these disorders and its proper
dose have not been ascertained with accuracy.
This salt, called also conicine and ciculine, is repre-
sented by the formula CH,17N,HBr.
Physical Properties.-This body occurs in trans-
parent colorless prisms.
Solubility.-This salt is soluble in water, and in alco-
hol in the proportion of I to 2 parts; it is slightly
soluble in ether.
Physiological Action.-The action of this salt is the
same as that of the mother-substance, conium. It acts
chiefly on the motor nerves. The sensory nerves and
the spinal cord are only feebly depressed, while the brain
remains unaffected. This drug produces paralysis of
the peripheral oculo-motor fibres, and thus dilates the
pupil. On the circulation the action is also a feeble one,
but in sufficiently large amounts the drug paralyzes the
Therapeutic Applications.- Coniine hydrobromate has
rendered good service as an antispasmodic and anti-
neuralgic in the treatment of whooping-cough, tetanus,
sciatica, and other affections of a similar nature.
Administration.-For adults the dose of the hydro-
bromate of coniine is A to - of a grain (0.002 to 0.004
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/74/: accessed March 24, 2019), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.