Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 76
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76 NOTES ON THE NEWER REMEDIES.
gramme); for children, -g to u of a grain (o.oooI to
Toxicology.--The chief symptoms of poisoning pro-
duced by coniine are those caused by hemlock itself.
They consist of giddiness, staggering, and disturbed
vision, followed by complete muscular relaxation. There
occur nausea, sometimes vomiting, frontal headache,
ptosis of the eyelids, and dilated pupils. The pulse is at
first slow and then becomes rapid. Salivation and sweat-
ing are sometimes observed. Death occurs from respi-
ratory failure. In case of poisoning the stomach should
be evacuated at once and tannic acid administered freely.
Hypodermatic injections of strychnine, caffeine, and
digitalis, together with the application of external heat
and artificial respiration, should be resorted to.
The glucoside of Conval/aria majalis, commonly called
the " lily-of-the-valley." The chemical nature of this
principle is represented by the formula C23H440,2.
Physical Properties.- Convallamnarin appears in the
form of a whitish-brown amorphous powder.
Solubility.-This drug is soluble in water and in alcohol.
Physiological Action.-The chief actions of this drug
appear to consist of a reduction of the pulse-rate and a
marked increase in the flow of urine. It rarely produces
nausea and vomiting.
Therapeutic Applications.-Convallamarin is chiefly
used as a cardiac stimulant. This remedy has been
found to be of special value in mitral stenosis with fail-
Administration.-The dose of convallamarin is from
I2 to I or 2 grains (0o.o03 to o.o6 or 0.12 gramme).
This is a second active principle of Convallaria majalis.
Physical Properties.-Convallarin occurs as a crys-
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/75/: accessed May 23, 2018), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.