Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 78
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NOTES ON THE NEWE R REMEDIES.
Administration. --Cornutine may be given in daily
doses of from s to 4 of a grain (o.oi to o.o 5 gramme).
For spermatorrhea this drug has been recommended in
daily amounts of from 2-o to 110 of a grain (0.003 to o.oo6
Of the two closely-allied species of this plant, Coro-
nilla scorpioides and Coronilla varia, the latter has been
found to be the more useful. No principles have been
extracted as yet.
Therapeutic Applications.-This drug is employed
as a heart-tonic, especially in cases where digitalis has
failed to be of service. Clinically, it has been found that
coronillin increases the energy of the cardiac muscle;
the pulse is strengthened and diuresis is increased, as a
consequence of which cedema and dyspncea are relieved.
But the effects of the drug appear to be of short dura-
tion. Coronilla itself seems to be indicated in painful
reflex symptoms of heart disease and in cardiac neurosis.
In these cases the drug seems to act as an anodyne. It
is likewise asserted that it possesses cathartic and diu-
Administration.-Two preparations of coronilla are
now in use: a tincture of the entire plant, of the strength
of I :5, the daily dose of it being from 2 to I fluid-
drachm (2 to 4 grammes); and a powder made from the
flowers, which is given in quantities of from 15 to 30
grains (I to 2 grammes) a day.
To a neutral principle obtained fi-om the bark of a
species of Nectandra there is given the name of cotoin,
its chemical composition being C22H180,.
Physical Properties.-This new agent occurs as an
amorphous crystalline powder of a pale yellowish color.
Solubility.-Cotoin is readily soluble in ether, alco-
hol, chloroform, and the alkalies; it is only slightly
soluble in water.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/77/: accessed December 12, 2018), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.