Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 85
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notic in a variety of nervous disorders. Its great value
in mental disease has been determined by recent trials;
in such cases the drug has been found superior to atro-
pine and morphine.
Administration.-The dose of this salt varies from
12- to ' of a grain (0.00054 to o.oo0 gramme), and it
may be given in amounts as high as - of a grain (o.oo2
Toxicology.-Even when locally applied to the eye,
duboisine is apt to cause toxic symptoms consisting of
disturbance of speech, a frequent pulse, great weakness,
and a rise of the bodily temperature. Among the first
of the untoward effects produced by the drug may be
mentioned dryness of the throat.
This new sweetening agent is the paraphenotol carba-
mide. It is known also under the name of sucrol.
Physical Properties.-With fuming nitric acid dulcin
will produce a beautiful orange-yellow substance. On
evaporating, sucrol will yield an orange-yellow residue;
this residue, treated with two drops each of liquid car-
bonic acid and concentrated sulphuric acid, will give an
intense blood-red coloration.
Physiological Action.-Given to rabbits in daily doses
of 30 grains (2 grammes), it exercises no deleterious
influence. The same results have been observed in the
case of dogs, and from experiments it has been deter-
mined that in these latter animals daily amounts of I2
grains (o.o9 gramme) per kilo (24 pounds) of the body-
weight produce no injurious effects.
Therapeutic Applications.-Dulcin has been em-
ployed with apparent success in the treatment of diabetes.
The drug is said to be well borne.
Administration.-Dulcin -can be given in doses of 2
of a grain (0.02 gramme) twice a day in the form of
pastilles. These may be employed for the purpose of
sweetening coffee or tea.
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/84/: accessed June 22, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.