Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 95
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per cent. For hypodermatic use solutions in olive oil
of from 3 to Io per cent. strength may be employed, the
dose being from % to I 2 grains (o.oi6 to o.o9 gramme).
This compound, which is the methyl-acetanilid, a sub-
stance closely allied to acetanilid or antifebrin, is obtained
by the interaction of acetyl chloride and monomethyl-
anilid. Exa/ghi is represented by the formula CH,-N-
Physical Properties. Methyl-acetanilid occurs as a
tasteless powder made up of crystalline acicular needles
with a melting-point of 2120 F. (I000 C.), and, without
decomposing, it boils at from 4640 to 482 F. (24o to
Solubility.-Exalgin is readily soluble in alcohol and
difficultly soluble in water.
Incompatibility.-This drug is incompatible with
sacylylic acid, but, singularly enough, it is not so with
the salicylate of sodium.
Physiological Action.-Nervous System.-Exalgin
acts chiefly on the cerebro-spinal axis. It diminishes
motor power and causes clonic convulsions of cerebral
Circulation.-Methyl-acetanilid is a cardiac depressant,
and, interfering with oxygenation of the blood, diminishes
oxyhamoglobin. Small doses increase the arterial pres-
Respiration.-Sufficiently large doses depress this
function, and death is usually caused by respiratory
Muscular System.-Intramuscular injections produce
local paralysis of this tissue.
Te'mperature.-This medicament reduces the bodily
temperature, but apparently has little or no action on
Therapeutic Applications.-This drug has been em-
ployed particularly as an analgesic and antiseptic. It is
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/94/: accessed April 29, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.