OncoLog, Volume 57, Number 8, August 2012 Page: 1

II

Preoperative Chemotherapy
Offers Best Outcomes for Patients
with Rare Bladder Cancer

By Amelia Scholtz
A combination of neoadjuvant
chemotherapy and surgery pro-
vides patients who have small-
cell urothelial cancer (SCUC) with
much longer survival times than
does initial surgery, the previous
standard treatment.

a,
U
ao
0

100%_-
80% -
60% -
60%-
40% -
20% -

0%

These improved survival times were shown in a retrospec-
tive study in vhich a team of investigators reviewed the
records of 172 patients treated for SCUC at The University
of Texas MD Anderson Cancer Center between 1985 and
2010. The findings were striking. The median overall sur-
vival time for patients treated with initial surgery-which is
still considered the standard treatment at many institutions-
was only 18.3 months. In contrast, the median overall sur-
vival time for patients treated with neoadjuvant chemotherapy
followed by surgery was 159.5 months-more than 13 years.
Five-year disease-specific survival rates also differed marked-
ly: 20% for those treated with initial surgery and 79% for
those who received neoadjuvant chemotherapy and surgery.

a)
U-)
C)
Ci)
mU

100% -
80% -
60%-
40% -
20%-

0%

0 50 100 150 200 250
Months

0

I I I -

50 100 150
Months

I I
200 250

Overall (left) and disease-specific survival from the time of diagnosis with small-cell

urothelial cancer in patients undergoing neoadjuvant

chemotherapy and cystectomy compared with those undergoing initial cystectomy Adapted from Lynch SP et al. Eur Uro 2012.

Psychological Concerns
for Cancer Patients
Anxiety and depression often
follow diagnosis
4

In Brief
Reports on recent
MD Anderson
research
6

House Call
Myths and facts about
cancer treatment

7

THE UNIVERSITY OF TEXAS
iMDAnderson
('eeQ Center

Making Cancer History

- Neoadjuvant chemoth
Adjuvant or no chemt

- Neoadjuvant chemotherapy
Adjuvant or no chemotherapy

q_

therapy
therapy

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University of Texas M.D. Anderson Cancer Center. OncoLog, Volume 57, Number 8, August 2012, periodical, August 2012; Houston, Texas. (https://texashistory.unt.edu/ark:/67531/metapth640047/m1/1/ocr/: accessed April 24, 2019), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting UNT Libraries Government Documents Department.

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