Investigations into the Nature, Causation, and Prevention of Texas or Southern Cattle Fever Page: 47
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THE NATURE OF TEXAS CATTLE FEVER.
not infrequently accompanied by h mnatoblasts. It must not be un-
derstood that the different stages of the anmmia are characterized by
the exclusive presence of one or the other of these changed forms.
The granular or "punctate" cells may be met with in the various
stages of the anemia. Likewise the diffusely stained forms are in a
few cases encountered with the punctate forms before the ansamia has
become advanced. But as a rule we meet first with the simply en-
larged corpuscles, next with the punctate" forms, and lastly with
the diffusely stained or 'tinted "'* forms and the haumatoblasts.
It is not desirable to go into any details concerning the nature of
these corpuscles, as this has already been done from the standpoint of
general pathology in another publication where the literature is also
taken into consideration.t A few remarks are, however, in order as
bearing upon an understanding of the disease before us. The various
modified forms of red corpuscles, which we have been considering, are
perhaps all embryonic or immature forms. They have been hastened
into the circulation from their place of manufacture, the red marrow of
the bones, to supply an urgent demand created by the destruction of
vast numbers of red corpuscles by the Texas fever parasite. This de-
mand grows more and more pressing as the number of corpuscles con-
tinues to go down, and consequently more and more immature tforms
are sent until the hmumatoblasts themselves, the progenitors of the
red corpuscles, appear. The reasons for considering them embryonic
or immature red corpuscles can not be entered into here. It must suf-
fice to state that a comparative study of the embryonic cells in the red
marrow and of these modified corpuscles in the circulation shows them
to be the same.
The stainable material in these new corpuscles may be some form of
protoplasm imperfectly converted into the discoplasm of the adult red
corpuscle. We have already presented the theory that the granules
may be derived from the diffusely stained material by a condensation
in the shed blood. This, of course, will demand special study. It is
enticing to interpret, as has been done, the larger granules as frag-
ments of the nucleus of the humatoblasts, but there are no observations
directly supporting this view. $
The same modified or embryonic forms of corpuscles appear in the
acute type of Texas fever after the high temperature has disappeared
and the stage of convalescence has begun. They disappear speedily
from the circulation when the number of corpuscles again begins to
rise. In fact they seem to disappear when the number has risen to 2.5
* These terms are used in the appendix to designate these modified corpuscles.
tTheobald Smith: On changes in the red blood corpuscles in thepernicious ansamia
of Texas cattle fever. Trans. Assoc. Amer. Physicians for 1891.
(It is a curious fact that the granular, or " punctate" cells have not been seen in
the parenchyma of the various organs (spleen, liver, kidneys), although the diffusely
stained or "tinted" cells are present.47
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Smith, Theobold & Kilborne, Fred Lucius. Investigations into the Nature, Causation, and Prevention of Texas or Southern Cattle Fever, book, 1893; Washington D.C.. (https://texashistory.unt.edu/ark:/67531/metapth143538/m1/47/: accessed July 16, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.