Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 110
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I IO NOTES ON THE NEWER REMEDIES.
Therapeutic Applications.-Hydrastine is useful in a
large variety of disorders as a stomachic and antiperi-
odic. It is of service also in diseases of the skin, catar-
rhal jaundice, as a uterine tonic, in leucorrhoea, metror-
rhagia, gonorrhoea, gleet, ear troubles, chronic inflam-
mations of the nose, etc. It has been used with alleged
advantage in chronic gastro-intestinal catarrhs, particu-
larly those met with in alcohol-drinkers.
Administration.-The dose of hydrastine may be
given as from 4 to 12 grain (o.ol5 to 0.03 gramme).
For gonorrhoea a solution may be used of the strength
of from i2 to I or 2 grains to the ounce (0.03 to o.o6
or 0.12 in 30.00 grammes). For external use ointments
of the strength of from Io to 6o grains to the ounce
(0.65 to 3.9 in 30.00 grammes) are recommended.
Toxicology.-No cases have been reported of serious
intoxication traceable to the use of the drug. If poison-
ing does occur, the symptoms will undoubtedly resemble
those produced by strychnine, and they should be treated
as such.
HYDRASTININE.
Hydrastininc, which is obtained from hydrastine by
a process of oxidation, is thus chemically constituted:
Physical Properties.-This drug occurs in acicular
crystals with a melting-point of from 240.8 to 242.6 F.
(I 16 to I 17 C.).
Solubility.--Hydrastinine is freely soluble in alcohol,
ether, and chloroform, and is but slightly soluble in
water.
Physiological Action.-The behavior of this sub-
stance is identical with that of hydrastine, except that it
does not appear to act upon the heart. HIydrastinine
elevates the arterial pressure by an action upon the vaso-
motor centres, and diminishes the pulse-rate by stimu-
lating the cardio-inhibitory centres. This drug kills
also through respiratory failure.
Therapeutic Applications.-The salt most generally
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (https://texashistory.unt.edu/ark:/67531/metapth143542/m1/109/: accessed April 26, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.