[Journal Article: Immune Modulation By Aspirin During Experimental Rhinovirus Colds] Page: 4 of 6
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J. HSIA AND OTHERS - I
TABLE II. EFFECTS OF ASPIRIN OR PLACEBO ON NASAL MUCUS PRODUCTION
IN EXPERIMENTAL RHINOVIRUS COLDS
Nasal mucus secretion (g)*
Treatment (N) Day 3 Day 4 Day 5 Day 6 Day 7 Total
Aspirin (9) 4.4 6.4 6.6 5.5 4.9 4.2 2.8 2.6 3.0 2.7 21.8 18.4
Placebo (9) 4.0 6.2 7.2 10.9 2.6 2.8 2.8 3.1 2.9 3.3 19.5 22.9
*Mean SDboth placebo and aspirin recipients was increased in the presence of thymosin
fraction 5 in vitro (Table III).
There was no relationship between the percent increase in interferon-y600
400
200E
0
0
0
C600 -
400
2001Aspirin
TF5+
+
+
+Fig. 4. Effect of oral aspirin or placebo on interferon--y production. Volunteers were ran-
domized to receive oral aspirin or placebo as described in "Methods." Lymphocytes were
isolated from heparinized blood samples obtained beforehand and 24 hours after the first dose.
Phytohemagglutinin-stimulated interferon-y production was determined in the absence or
presence of aspirin, 300 M, or thymosin fraction 5, 300 g/ml, in vitro. Single asterisks
indicate p <0.05, double asterisks indicate p <0.01.TABLE III. STIMULATION OF INTERFERON--y AND INTERLEUKIN-2
PRODUCTION BY THYMOSIN FRACTION 5 IN VITRO FOLLOWING ORAL
ASPIRIN OR PLACEBO.
Treatment (N) Day 1 Day 2 Day 6
Change in interferon-y production
Placebo 9 2% 24% 21%
Aspirin 9 30% 14% 18%
Change in interleukin-2 production
Placebo 9 28% 16% 39%
Aspirin 9 23% 6% 55%
Peripheral blood lymphocytes from blood samples collected on the indicated days from aspirin and
placebo recipients were incubated with phytohemagglutinin (Ipg/ml for interferon-y assays, 2 g/ml for
interleukin-2 assays) in the absence or presence of thymosin fraction 5, 300 g/ml, as described in
"Methods." Data represent the percent increase in production of interleukin-2 or interferon-y by lympho-
cytes following incubation with phytohemagglutinin and thymosin fraction 5 compared to phytohemag-
glutinin alone.
production from days one to two, one to six, or two to six and symptom
scores, nasal mucus production, viral titers, or days of virus shedding
whether the aspirin and placebo groups were analyzed separately or
combined.
Interleukin-2 production by peripheral blood lymphocytes. Phytohemag-
glutinin-stimulated interleukin-2 production by peripheral blood lympho-
cytes from blood samples collected 24 hours after the first dose of aspirin was
increased by 135% compared to interleukin-2 production by lymphocytes
from blood samples before aspirin. In contrast, interleukin-2 production by
lymphocytes from placebo recipients rose only 34% from day one to two of
the study (Figure 5). Similarly, large increases in interleukin-2 production
from day one to day two were observed when peripheral blood lymphocytes
from oral aspirin recipients were incubated with additional aspirin or thy-
mosin fraction 5 or both in vitro (Figure 5).
Phytohemagglutinin-stimulated interleukin-2 production by peripheral
blood lymphocytes from blood samples collected on days one, two, or six of
the study from either treatment group was augmented by incubation with
thymosin fraction 5 in vitro (Table III).
DISCUSSION
This study is the first to demonstrate enhanced in vitro production of two
cytokines, interferon-'y and interleukin-2, following oral aspirin in man.
Phytohemagglutinin-stimulated interferon-y production was significantly in-Vol. 65, No. 1, January, 1989
Placebo EJ Day 1
Day 2Aspirin
4 *" **L
1 52
ii
MODULATION BY ASPIRIN
51
Bull. N.Y. Acad. Med.
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Bulletin of the New York Academy of Medicine. [Journal Article: Immune Modulation By Aspirin During Experimental Rhinovirus Colds], text, January 1989; (https://texashistory.unt.edu/ark:/67531/metadc786211/m1/4/: accessed April 26, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting UNT Libraries Special Collections.