[Letter from C. J. Weber to Meyer Bodansky - November 1935] Page: 1 of 2
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THE UNIVERSITY OF KANSAS
THE SCHOOL OF MEDICINE
KANSAS CITY, KANSAS
DEPARTMENT OF INTERNAL MEDICINE November 29, 1935
Dr. Meyer Bodansky
University of Texas
School of Medicine
Galveston, Texas
My dear Doctor Bodansky:
I am sorry for the delay in answering your letter. I was
glad to hear that you have found the method satisfactory for urine.
I have not had the opportunity to make a detailed study of its
application to tissue analysis. I have attempted it with blood
using essentially the seme procedure as with urine using trichloracetic
acid as the protein precipitant. My results would indicate that the
concentration of guanidine acetic acid in blood is in the neighborhood
of about 0.05 mg. per 100 c.c. With these small amounts m:; values are,
of course, only rough approximations. In some early work I made one
attempt at determining the concentrations in tissues and at that time
decided that there was not over 0.5 mg. per 100 gmis. muscle tissue.
Here, again, is only a very rough approximation. You can see that the
application of this method is beset with difficulties and it will
probably be impossible to ever prove by direct isolation that this
small amount of substance giving the Sakaguchi reaction is really
guanidine acetic acid.
I want you to feel at liberty to apply this method to tissues
or blood.
The finding of these small amounts in blood and yet finding
appreciable quantities in urine has been the source of a little worry.
Unless it would happen to be actually produced in the kidneys it appears
that the substance may be excreted by the kidneys in a concentration
which approaches that of any waste product existing in like concentrations
in the blood.
The above statement is, of course, my own personal impression
at present. I would be glad to hear of any further developments in your
laboratory.
Yours sincerely,
(C . Weber
Department of Experimental
CJW:S Medicine.
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Weber, C. J. [Letter from C. J. Weber to Meyer Bodansky - November 1935], letter, November 29, 1935; (https://texashistory.unt.edu/ark:/67531/metapth228102/m1/1/: accessed May 7, 2024), University of North Texas Libraries, The Portal to Texas History, https://texashistory.unt.edu; crediting Moody Medical Library, UT.