Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition Page: 57
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BUTYL-CHLORAL HYDRA TE.
bryonine, which by some investigators is said to be a
glucoside, is represented by the formula CHs80119.
Physiological Action.-The action of this plant is
not well known. It acts, however, as a gastro-intestinal
irritant, producing profuse watery discharges. In small
amounts it causes flushing of the face and often head-
ache. Large doses exercise a decided influence also on
serous membranes, and it is said that poisonous quanti-
ties are apt to produce symptoms of meningitis.
Therapeutic Applications.-The plant itself is used
in the treatment of whooping-cough. It has been highly
recommended in atonic dyspepsia and in constipation
of children, particularly when this latter condition is
dependent on insufficient intestinal secretion. Bryonia
is well spoken of also in diseases of the chest, such as
pleurisy, and similarly in rheumatism. Bryonine has
been recommended in hemorrhages.
Administration.- Byonia may be given in the form
of powder, in doses of from 7'2 grains to I drachm (0.5
to 4 grammes). A tincture of the plant is administered
in doses of from I to 2 fluidrachms (3.75 to 7.50 cc.).
This body, which is also known by the name of croton-
chloral zydrate, is produced by the action of chlorine
upon aldehyde, its formula being C4HCI30,H20.
Physical Properties.-Butyl-chloral hydrate occurs in
brilliant crystalline tables.
Solubility.-This drug is soluble in rectified spirits,
but only slightly soluble in water.
Physiological Action.-On the whole, the physio-
logical action of this substance may be said to be similar
to that of chloral hydrate; but the drug under consider-
ation is said to possess more analgesic power and to be
less depressant to the circulation, particularly the heart.
Large doses, however, paralyze the cardiac viscus, this
phenomenon being preceded by disturbances of respira-
tion and greatly reduced blood-pressure. This drug is
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Cerna, David. Notes on the Newer Remedies: Their Therapeutic Applications and Modes of Administration, Second Edition, book, 1894; Philadelphia, Pennsylvania. (texashistory.unt.edu/ark:/67531/metapth143542/m1/56/: accessed October 21, 2017), University of North Texas Libraries, The Portal to Texas History, texashistory.unt.edu; crediting University of Texas Health Science Center Libraries.